Urea denaturation promoted bovine beta-lactoglobulin fibrillogenesis
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چکیده
منابع مشابه
Urea and Guanidine Hydrochloride Denaturation of Ribonuclease, Lysozyme, &Zhymotrypsin, and @Lactoglobulin*
The unfolding of ribonuclease, lysozyme, a-chymotrypsin, and goat P-lactoglobulin by urea and guanidine hydrochloride (GmHCl) has been followed with the use of optical rotation measurements. Urea denaturation leads to a more negative rotation for each protein than does GmHCl denaturation, but the concentration dependence is such that the rotations are almost identical in the absence of denatura...
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We have reported in a previous paper (1) that optical rotatory dispersion measurements indicate that the native conformation of P-lactoglobulin, in aqueous solution, contains few, if any, regions with an a-helical structure. It appears likely, from the many studies of Jirgensons (2) that this conclusion is applicable to a large number of globular proteins, and we have suggested that this indica...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2001
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.41.s168_3